What to do with replies to spam?

Almost a month ago I blogged about how much spam I receive. At that time it was around one spam email per 100 seconds (average over the previous month). Since then I've updated my crude spam rate tracker twice and I'm now receiving approximately one spam every 90 seconds. If you look at the numbers carefully you'll noticed that today's count was less for all mailboxes except one; N L AR, the catch-all address for lucion.com.ar. The spam count for that mailbox increased dramatically from about 1000 to almost 4000. Most interestingly, I received almost 150 automated replies to spam messages from unused @lucion.com.ar addresses:

screenshot of mailbox with many automated replies to spam emails from unused @lucion.com.ar addresses

It would seem that a spammer is targeting lucion.com.ar as both a fictitious from address for their outgoing spam, and a spam recipient. Why would lucion.com.ar be targeted? Does anyone know how to foil this targeted spam? Should I turn off catch-all? Set up SPF?

I've also started receiving comment spam on this blog. Probably average about 3 per day -- all of the same style; usinge BB-code, random letters as titles and usernames and probably from the same botnet (they're from many unrelated IPs). Since I'm running this on drupal 6 RC1 I haven't put up any anti-spam defenses other than having all comments moderated. I assume that most or all of the best anti-comment spam contrib modules have not yet been ported to drupal 6. Are there any?

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Comments

You are not specifically targeted

You are not selected!

Being spammed and having your addresses used for spamming is "standard practice" from the spammers. Usually they make up fake addresses though.

So if you can:
as said above, only accept mail to valid addresses and block the others
consider using blocklists (RBL) to not accept mail from known spamsites. You have to be careful in your selection, not to block valid mail.
use greylisting to weed out trojaned PC that are not yet in the RBL's
don't accept mail from senders persenting themselves with your "name" or IP

Don't ever accept a mail and then bounce it! If you do, you just add to the amount of junk, and you might get into blocklists for it.

/BoK

You could also create a white

You could also create a white list of email addresses you want to use, so that the spam mails to all the other aliases won't get to you.

Set up SPF

SPF record should help cut down on the people being able to use your domain as a from address.

Of course turning off the catch-all address would help as well - but this depends on your needs.